1 Cook the pasta: Bring a large pot of salted water to a boil. Add the macaroni and cook until al dente according to the package instructions. Drain and set aside.

2 Make the roux: In a large saucepan, melt 2 tablespoons of butter over medium heat. Whisk in the flour and cook for 1-2 minutes until lightly golden and bubbling.

3 Add milk and cream: Slowly whisk in the milk and heavy cream, stirring constantly until the mixture thickens, about 4-5 minutes.

4 Stir in the cheeses: Reduce the heat to low and add all five cheeses, reserving a small amount of cheddar and mozzarella for topping. Stir until completely melted and smooth. Add garlic powder, onion powder, salt, and pepper to taste.

5 Combine pasta and cheese sauce: Add the cooked macaroni to the cheese sauce and stir to coat evenly.

6 Transfer to a baking dish: Pour the mixture into a greased 9×13 inch baking dish. Sprinkle the reserved cheddar and mozzarella on top.

7 Add topping and bake: If using, melt 1 tablespoon of butter and toss with the panko breadcrumbs. Sprinkle evenly over the top. Bake at 375°F (190°C) for 20-25 minutes, or until the top is golden and bubbly.